02153nas a2200205   4500008004100000245014200041210007300183520141100256653001601667653002201683653003001705653003001735653001101765653001301776653002801789100002101817700002201838700002501860856006201885       2019                        eng d00aPerinatal high‐fat diet impairs pup retrieval and induces sex‐specific changes in ultrasonic vocalization characteristics of rat pups0 aPerinatal high‐fat diet impairs pup retrieval and induces sex‐sp3 a<p>Rodent pups emit ultrasonic vocalizations (USVs) to solicit maternal behavior, promoting their survival. Conversely, maternal behaviors affect the expression of pup USVs. We previously demonstrated that a maternal diet high in saturated fat (HFD) alters maternal behavior and is associated with early maturation of pups and their stress physiology. Here, we assessed the developmental profiles of pup USVs using quantitative and qualitative measures on postnatal days (PND)7 and 13. Quantitative measures included call counts, duration, and frequency, while qualitative measures examined calls&#39; sonographic structures. HFD offspring lacked the typical decrease in USV numbers with age observed among control offspring. They also had shorter calls at PND7 compared to control and HFD offspring at PND13. HFD female offspring showed a greater number of one‐frequency‐sweep calls, while male pups showed a greater number of two‐frequency‐sweep calls compared to control offspring. Concomitantly, HFD dams showed impaired pup retrieval on PND7. The data suggest that fewer USVs of shorter duration in HFD offspring may alter dam solicitation and thus impair maternal pup retrieval. This study highlights the impacts of perinatal HFD exposure on the dyadic reciprocal interaction between dam and pups, which may set the stage for long‐lasting effects on offspring physiology and behavior.</p>
10adevelopment10amaternal behavior10amother–pup interactions10aperinatal high‐fat diet10arodent10asonogram10aultrasonic vocalization1 aAbuaish, Sameera1 aTse, Emmanuel, K.1 aMcGowan, Patrick, O.  uhttps://onlinelibrary.wiley.com/doi/abs/10.1002/dev.21923